It is also known as HAPPY PUPPET SYNDROME and it is a genetic disorder that affects your nervous system. It can be misdiagnosed as palsy or autism, so the correct diagnosis and differentiation should be done. It causes severe physical and intellectual disability.
The cause is due to genetic mutation and due to lack of function of part of chromosome 15 inherited from a patient’s mother. It is due to the deletion or mutation of the UBE3A gene on the chromosome due to inherited two copies of chromosome 15 from the patient’s father and none from their mother because of genomic imprinting. It can also be caused due to chromosome translocation in the UBE3A gene. Loss of the OCA2 gene is also linked to one of the causes.